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The best known commercial polysaccharopeptide preparations of Trametes versicolor are Polysaccharopeptide Krestin(PSK) and polysaccharopeptide PSP. Both products are obtained from the extraction of Trametes versicolor mycelia.

PSK and PSP are Japanese and Chinese products, respectively. Both products are obtained by batch fermentation. PSK fermentation lasts up to 10 days, whereas PSP production involves a 64-h culture. PSK recovered from hot water extracts of the biomass by salting out with ammonium sulfate,whereas PSP is recovered by alcoholic precipitation from the hot water extract.

Polysaccharide-K (PSK or krestin), extracted from T. versicolor, is considered safe for use as an adjunct therapy for cancer treatment in Japan where it is known as kawaratake (roof tile mushroom) and approved for clinical use. As a glycoprotein mixture, PSK has been studied in clinical research in people with various cancers and immune deficiencies, but its efficacy remains inconclusive, as of 2021.

In some countries, PSK is sold as a dietary supplement. Use of PSK may cause adverse effects, such as diarrhea, darkened feces, or darkened finger nails. —From WIKIPEDIA